tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate
CAS No.:1357614-78-8
Molecular Formula:C₁₈H₂₃BrN₂O₄
Molecular Weight:411.296
Hs Code.:

Synonyms:tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

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Technology Process of tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

There total 5 articles about tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1357614-77-7
3-(2-bromo-4-(dimethoxymethyl)phenyl)azetidine-3-carbonitrile

: 1357614-78-8
tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

: C₁₆H₁₇BrN₂O₃

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: C₁₅H₁₉BrN₂O₂

: 1357614-78-8
tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

: C₁₆H₁₇BrN₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1: 0.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: 1357614-78-8
tert-butyl 3-(2-bromo-4-(dimethoxymethyl)phenyl)-3-cyanoazetidine-1-carboxylate

: C₁₆H₁₇BrN₂O₃

Guidance literature:: Multi-step reaction with 5 steps

1: tetra-N-butylammonium tribromide / ethanol / 20 °C

2: potassium hexamethylsilazane / tetrahydrofuran / 20 °C

3: 2-Chloroethyl chloroformate / acetonitrile / 3 h / 0 °C / Reflux

4: 0.5 h / Reflux

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With tetra-N-butylammonium tribromide; potassium hexamethylsilazane; 2-Chloroethyl chloroformate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;