4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

Base Information

Chemical Name:4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium
CAS No.:118409-75-9
Molecular Formula:C₂₁H₂₃ClN₅O
Molecular Weight:396.9
Hs Code.:

Synonyms:4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

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Chemical Property of 4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

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Technology Process of 4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

There total 6 articles about 4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-Amino-phenyl)-8-[1-(4-chloro-phenyl)-ethyl]-1,3,8-triaza-spiro[4.5]decan-4-one

: 118409-75-9
4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; sodium nitrite; In water; at -20 ℃; for 0.5h;
DOI:10.1021/jm00171a020

Reference yield:

: 99-91-2
para-chloroacetophenone

: 118409-75-9
4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

Guidance literature:: Multi-step reaction with 4 steps

1: 27 percent / NaBH₃CN, AcOH / methanol / 72 h / Ambient temperature

2: 40 percent / NaNO₂, concd. HCl / 1 h / Ambient temperature

3: H₂ / 10percent Pd/C / methanol / 2 h / 2280 Torr

4: sodium nitrite, TFA, concd. HCl / H₂O / 0.5 h / -20 °C

With hydrogenchloride; hydrogen; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00171a020

Reference yield:

: 128659-83-6
1-(p-nitrosophenyl)-8-<1-(4-chlorophenyl)ethyl>-1,3,8-triazaspiro<4.5>decan-4-one

: 118409-75-9
4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaza-spiro[4.5]dec-1-yl}-benzenediazonium

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 2 h / 2280 Torr

2: sodium nitrite, TFA, concd. HCl / H₂O / 0.5 h / -20 °C

With hydrogenchloride; hydrogen; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00171a020