(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

Base Information

Chemical Name:(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide
CAS No.:1067648-50-3
Molecular Formula:C₂₁H₂₃F₃N₄O₃
Molecular Weight:436.434
Hs Code.:

Synonyms:(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

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Chemical Property of (2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

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Technology Process of (2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

There total 9 articles about (2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1067648-43-4
5-azido-2,3,5-trideoxy-6-O-(3,5-difluorobenzyl)-2-methyl-L-idono-1,4-lactone

: 140-75-0
para-fluorobenzylamine

: 1067648-50-3
(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

Guidance literature:: With 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 96h; Reflux;
DOI:10.1016/j.ejmech.2009.11.013

Reference yield: 88.0%

: 1067648-50-3
(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

Guidance literature:

Reference yield:

: 1067648-41-2
2,3-dideoxy-2-methyl-D-glucono-1,4-lactone

: 1067648-50-3
(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid 4-fluorobenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: di(n-butyl)tin oxide / toluene / 5 h / Reflux

1.2: 90 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 0 °C

2.2: 0 - 20 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / Reflux

With 2-hydroxypyridin; di-isopropyl azodicarboxylate; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2009.11.013