3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Base Information

Chemical Name:3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole
CAS No.:1345860-99-2
Molecular Formula:C₁₆H₁₅N₃O₄S
Molecular Weight:345.379
Hs Code.:

Synonyms:3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

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Chemical Property of 3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

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Technology Process of 3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

There total 3 articles about 3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 4-ethylbenzoic acid [(5-nitrothiophen-2-yl)methylene]hydrazide

: 108-24-7
acetic anhydride

: 1345860-99-2
3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Guidance literature:: at 85 - 120 ℃; for 8h;
DOI:10.1016/j.bmc.2011.09.009

Reference yield:

: 7364-20-7
4-ethyl-benzoic acid methyl ester

: 1345860-99-2
3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / water / 0.17 h / 75 °C

2: sulfuric acid; acetic acid / methanol; water / 1 h / Reflux

3: 8 h / 85 - 120 °C

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol; water;
DOI:10.1016/j.bmc.2011.09.009

Reference yield:

: 619-64-7
p-ethylbenzoic acid

: 1345860-99-2
3-acetyl-5-(4-ethylphenyl)-2-(5-nitrothiophen-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 4 h / Reflux

2: hydrazine hydrate / water / 0.17 h / 75 °C

3: sulfuric acid; acetic acid / methanol; water / 1 h / Reflux

4: 8 h / 85 - 120 °C

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol; water;
DOI:10.1016/j.bmc.2011.09.009