3-{4-[(benzylamino)sulfonyl]phenyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)propanamide

Base Information

Chemical Name:3-{4-[(benzylamino)sulfonyl]phenyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)propanamide
CAS No.:708219-05-0
Molecular Formula:C₂₄H₂₄N₂O₅S
Molecular Weight:452.531
Hs Code.:
Mol file:708219-05-0.mol

Synonyms:N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-[(phenylmethyl)aminosulfonyl]-phenyl]propanamide

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Chemical Property of 3-{4-[(benzylamino)sulfonyl]phenyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)propanamide

Chemical Property:

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Technology Process of 3-{4-[(benzylamino)sulfonyl]phenyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)propanamide

There total 6 articles about 3-{4-[(benzylamino)sulfonyl]phenyl}-N-(2,3-dihydro-1,4-benzodioxin-6-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₆ClNO₃S

: 22013-33-8
6-amino-3,4-benzodioxane

: 708219-05-0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-[(phenylmethyl)aminosulfonyl]-phenyl]propanamide

Guidance literature:: With pyridine; at 25 ℃;
DOI:10.1016/j.bmcl.2011.12.011

Reference yield:

: 374537-95-8
methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

: 708219-05-0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-[(phenylmethyl)aminosulfonyl]-phenyl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 2 h / 25 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 10 h / 20 °C

3: oxalyl dichloride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

4: pyridine / 25 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.12.011

Reference yield:

: 1357115-97-9
C₁₇H₁₉NO₄S

: 708219-05-0
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-[(phenylmethyl)aminosulfonyl]-phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 10 h / 20 °C

2: oxalyl dichloride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3: pyridine / 25 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.12.011