4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

Base Information

Chemical Name:4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester
CAS No.:1028302-56-8
Molecular Formula:C₃₂H₄₆N₂O₅
Molecular Weight:538.728
Hs Code.:

Synonyms:4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

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Chemical Property of 4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

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Technology Process of 4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

There total 6 articles about 4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026878-22-7
4-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

: 1028302-56-8
4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

Guidance literature:: With tetrachloromethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; acetonitrile; at 25 ℃;
DOI:10.1021/jm00062a013

Reference yield:

4-cyclohexyl-1-butanamine hydrochloride: 91342-30-2
4-cyclohexyl-1-butanamine hydrochloride

: 1028302-56-8
4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxybenzotriazole, 4-methylmorpholine, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / Ambient temperature

2: 12.7 g / trifluoroacetic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

4: PPh₃, CCl₄, (iPr)2NEt / acetonitrile; CH₂Cl₂ / 25 °C

With 4-methyl-morpholine; tetrachloromethane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00062a013

Reference yield:

: 135613-44-4
<1S-1α,2α,3α,4α>-2-<<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzenebutanoic acid, methyl ester

: 1028302-56-8
4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CrO₃, H₂SO₄ / acetone / 25 °C

2: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

3: PPh₃, CCl₄, (iPr)2NEt / acetonitrile; CH₂Cl₂ / 25 °C

With chromium(VI) oxide; tetrachloromethane; sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00062a013