Technology Process of tert-butyl (2S,4S)-N-(tert-butoxycarbonyl)-5-hydroxy-<5,5-(2)H2>leucine
There total 1 articles about tert-butyl (2S,4S)-N-(tert-butoxycarbonyl)-5-hydroxy-<5,5-(2)H2>leucine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 83 percent / 1,2-dimethoxy-ethane / 16 h / 75 °C
2: 69 percent / DIBAL / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) r.t., 2 h
3: 86 percent / H2 / 10percent Pd/C / methanol / 24 h / Ambient temperature
4: 94 percent / aq. lithium hydroxide / tetrahydrofuran / 0.25 h / 0 °C
5: triethylamine / tetrahydrofuran / 1 h / -40 °C
6: sodium tetradeuteroboranuide / tetrahydrofuran; D2O / 1.5 h / Ambient temperature
With
lithium hydroxide; sodium borodeuteride; hydrogen; diisobutylaluminium hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water-d2;
DOI:10.1039/p19960000507
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 97 percent / pyridine / CH2Cl2 / 20 °C
2: 85 percent / DMAP / acetonitrile / 20 °C
3: 62 percent / tetrabutylammonium fluoride; 2-mesitylenesulfonic acid dihydrate / tetrahydrofuran / 72 h / 50 - 52 °C
4: 85 percent / aq. HCl / 96 h / 20 °C
5: 89 percent / aq. Na2CO3 / acetone / 20 °C
With
pyridine; hydrogenchloride; dmap; mesitylene-2-sulfonic acid dihydrate; tetrabutyl ammonium fluoride; sodium carbonate;
In
tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1039/b314933a
