(1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester

Base Information

• Chemical Name: (1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester
• CAS No.: 170096-59-0
• Molecular Formula: C₂₂H₃₂N₄O₆
• Molecular Weight: 448.519

Synonyms:(1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester

Chemical Property of (1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester

Chemical Property:

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Technology Process of (1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester

There total 5 articles about (1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

{1-[(S)-2-(4-Cyano-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester (178601-16-6) → (1-{(S)-2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester (170096-59-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 23 ℃; for 14h;

DOI:10.1021/jm9509298

Reference yield:

{1-[(S)-2-(4-Cyano-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester (178601-16-6) → (1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester (170096-59-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 20 ℃; for 48h;

DOI:10.1002/jccs.200100024

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → (1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester (170096-59-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 97 percent / dioxane; H₂O / 1 h / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 36 percent / tetrahydrofuran / 3 h / Heating

3.1: NH₂OH*HCl; MeONa / methanol / 48 h / 20 °C

With hydroxylamine hydrochloride; sodium methylate; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1002/jccs.200100024

upstream raw materials:

{1-[(S)-2-(4-Cyano-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester

4-HYDROXYPIPERIDINE

4-cyano-N-[2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-ethyl]-benzamide

9H-fluoren-9-ylmethyl 4-hydroxy-1-piperidinecarboxylate

Downstream raw materials:

Ro 48-3656

sibrafiban

(1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid

sibrafiban

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