1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

Base Information

Chemical Name:1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione
CAS No.:1188541-28-7
Molecular Formula:C₂₄H₂₂F₃N₅O₄
Molecular Weight:501.465
Hs Code.:

Synonyms:1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

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Chemical Property of 1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

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Technology Process of 1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

There total 7 articles about 1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₆F₃N₅O₅Si

: 1188541-28-7
1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

Guidance literature:: With hydrogenchloride; In ethanol; at 80 ℃; for 2h;
DOI:10.1016/j.ejmech.2017.04.014

Reference yield:

: C₂₇H₃₇N₅O₅Si

: 1188541-28-7
1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

2: potassium carbonate / acetone / 5 h / Reflux

3: hydrogenchloride / ethanol / 2 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2017.04.014

Reference yield:

: C₂₁H₂₃N₅O₄

: 1188541-28-7
1,3-dipropyl-8-{3-[3-(3-trifluoromethylphenyl)prop-2-ynyloxy]isoxazol-5-yl}-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

3: potassium carbonate / acetone / 5 h / Reflux

4: hydrogenchloride / ethanol / 2 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2017.04.014