9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

Base Information

Chemical Name:9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine
CAS No.:480427-62-1
Molecular Formula:C₁₈H₁₄F₃N₅O₃
Molecular Weight:405.336
Hs Code.:

Synonyms:9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

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Chemical Property of 9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

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Technology Process of 9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

There total 4 articles about 9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (2S,3R,4R,5R)-5-(6-amino-purin-9-yl)-4-methanesulfonyloxy-3-trifluoromethyl-tetrahydro-furan-2-ylmethyl ester

: 480427-62-1
9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1081/NCN-100002423

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 480427-62-1
9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / SnCl₄ / acetonitrile / 14 h / 20 °C

2: 76 percent / hydrazine hydrate; acetic acid; pyridine / 60 h

3: pyridine / 7 h / 20 °C

4: 0.242 g / tetrabutylammonium fluoride / tetrahydrofuran / 21 h / 50 °C

With pyridine; tetrabutyl ammonium fluoride; tin(IV) chloride; hydrazine hydrate; acetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0968-0896(02)00216-X

Reference yield:

: 377077-50-4
9-(5-O-benzoyl-3-deoxy-3-trifluoromethyl-β-D-ribofuranosyl)adenine

: 480427-62-1
9-(5-O-benzoyl-2,3-dideoxy-3-trifluoromethyl-β-D-glycero-pent-2-eno-furanosyl)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 7 h / 20 °C

2: 0.242 g / tetrabutylammonium fluoride / tetrahydrofuran / 21 h / 50 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0968-0896(02)00216-X