C₄₀H₅₁NO₇Si

Base Information

Chemical Name:C₄₀H₅₁NO₇Si
CAS No.:272440-02-5
Molecular Formula:C₄₀H₅₁NO₇Si
Molecular Weight:685.933
Hs Code.:

C<sub>40</sub>H<sub>51</sub>NO<sub>7</sub>Si

Synonyms:C₄₀H₅₁NO₇Si

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Chemical Property of C₄₀H₅₁NO₇Si

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Technology Process of C₄₀H₅₁NO₇Si

There total 1 articles about C₄₀H₅₁NO₇Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 5804-85-3
diethylaluminium cyanide

: C₃₉H₅₀O₇Si

: 272440-02-5
C₄₀H₅₁NO₇Si

Guidance literature:: In toluene; at 20 ℃; for 3h;
DOI:10.1021/ja9939439

Reference yield:

: 272440-02-5
C₄₀H₅₁NO₇Si

: 33069-62-4
taxol

Guidance literature:: Multi-step reaction with 32 steps

1.1: 88 percent / KH; hexamethyldisilazane / tetrahydrofuran / 0.2 h / 0 °C

2.1: 78 percent / DIBAL / CH₂Cl₂; hexane / 0.2 h / -78 °C

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 0.3 h / -78 °C

4.1: 88 percent / triphenylphosphine; carbon tetrabromide; pyridine / benzene / 0.5 h / 50 °C

5.1: 100 percent / aq. HCl / acetone / 0.5 h / 20 °C

6.1: 100 percent / SmI₂; methanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 5 h / 20 °C

7.1: TBAF; 2,6-di-t-butyl-4-hydroxytoluene / tetrahydrofuran / 3 h / 20 °C

7.2: 45 percent / sodium methoxide / methanol; tetrahydrofuran / 60 h / 20 °C

8.1: pyridine / CH₂Cl₂ / 0.25 h / 20 °C

9.1: 2,6-lutidine / CH₂Cl₂ / 12 h / -45 °C

10.1: 6.6 mg / aq. hydrogen peroxide; aq. Na₂CO₃ / ethyl acetate / 1 h / 20 °C

11.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

12.1: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.08 h / 20 °C

13.1: KHMDS / tetrahydrofuran / 0.5 h / -78 °C

13.2: 89 percent / tetrahydrofuran / 1 h / -78 °C

14.1: 91 percent / tetrakis(triphenylphosphine)palladium / diethyl ether; tetrahydrofuran / 1 h / 20 °C

15.1: 88 percent / N-chlorosuccinimide / methanol / 10 h / 20 °C

16.1: 89 percent / pyridinium p-toluenesulfonate; 2-methoxypropene / CH₂Cl₂ / 0.05 h / 20 °C

17.1: 80 percent / lithium diisopropyl amide; MoO₅*pyridine*HMPA / tetrahydrofuran / 0.92 h / -23 °C

18.1: 92 percent / DMAP / CH₂Cl₂ / 0.5 h / 20 °C

19.1: 68 percent / DBN / toluene / 10 h / Heating

20.1: 86 percent / OsO₄; pyridine / diethyl ether; tetrahydrofuran / 18 h / 20 °C

21.1: 86 percent / DBU / toluene / 4 h / Heating

22.1: pyridinium p-toluenesulfonic acid / methanol / 0.5 h / 20 °C

23.1: 15 mg / DMAP; imidazole / dimethylformamide / 5 h / 20 °C

24.1: 97 percent / H₂ / Pd(OH)2 / ethanol / 1 h / 20 °C

25.1: 94 percent / pyridine / CH₂Cl₂ / 1 h / -78 - 0 °C

26.1: 66 percent / DMAP / CH₂Cl₂ / 6 h / 20 °C

27.1: 83 percent / tetrahydrofuran / 0.33 h / -78 °C

28.1: 88 percent / HF*pyridine / tetrahydrofuran / 2 h / 20 °C

29.1: 94 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

30.1: 80 percent / TASF / tetrahydrofuran / 48 h / 20 °C

31.1: 77 percent / LHMDS / tetrahydrofuran / -78 - 0 °C

32.1: 84 percent / Zn; aq. AcOH / 16 h / 20 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; methanol; dmap; N-chloro-succinimide; osmium(VIII) oxide; lithium aluminium tetrahydride; samarium diiodide; oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; carbon tetrabromide; 2-Methoxypropene; 2,6-dichloro-benzonitrile; tetrabutyl ammonium fluoride; tris(dimethylamino)sulfonium trimethylsilyldifluoride; hydrogen; dihydrogen peroxide; 2,6-di-tert-butyl-4-hydroxytoluene; pyridinium p-toluenesulfonate; potassium hydride; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium carbonate; Dess-Martin periodane; pyridine hydrogenfluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hexamethyldisilazane; zinc; lithium diisopropyl amide; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; benzene; 1.1: silylation / 2.1: Reduction / 3.1: Reduction / 4.1: Cyclization / 5.1: Ring cleavage / 6.1: Ring cleavage / 7.1: desilylation / 7.2: Isomerization / 8.1: cyclocondensation / 9.1: silylation / 10.1: Ring cleavage / 11.1: Dess-Martin oxidation / 12.1: Addition / 13.1: Metallation / 13.2: Condensation / 14.1: Condensation / 15.1: Chlorination / 16.1: Elimination / 17.1: hydroxylation / 18.1: Acetylation / 19.1: Isomerization / 20.1: hydroxylation / 21.1: Cyclization / 22.1: cleavage / 23.1: si;
DOI:10.1021/ja9939439

Reference yield:

: 272440-02-5
C₄₀H₅₁NO₇Si

: 219780-89-9
C₃₇H₅₅ClO₇Si

Guidance literature:: Multi-step reaction with 17 steps

1.1: 88 percent / KH; hexamethyldisilazane / tetrahydrofuran / 0.2 h / 0 °C

2.1: 78 percent / DIBAL / CH₂Cl₂; hexane / 0.2 h / -78 °C

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 0.3 h / -78 °C

4.1: 88 percent / triphenylphosphine; carbon tetrabromide; pyridine / benzene / 0.5 h / 50 °C

5.1: 100 percent / aq. HCl / acetone / 0.5 h / 20 °C

6.1: 100 percent / SmI₂; methanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 5 h / 20 °C

7.1: TBAF; 2,6-di-t-butyl-4-hydroxytoluene / tetrahydrofuran / 3 h / 20 °C

7.2: 45 percent / sodium methoxide / methanol; tetrahydrofuran / 60 h / 20 °C

8.1: pyridine / CH₂Cl₂ / 0.25 h / 20 °C

9.1: 2,6-lutidine / CH₂Cl₂ / 12 h / -45 °C

10.1: 6.6 mg / aq. hydrogen peroxide; aq. Na₂CO₃ / ethyl acetate / 1 h / 20 °C

11.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

12.1: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.08 h / 20 °C

13.1: KHMDS / tetrahydrofuran / 0.5 h / -78 °C

13.2: 89 percent / tetrahydrofuran / 1 h / -78 °C

14.1: 91 percent / tetrakis(triphenylphosphine)palladium / diethyl ether; tetrahydrofuran / 1 h / 20 °C

15.1: 88 percent / N-chlorosuccinimide / methanol / 10 h / 20 °C

16.1: 89 percent / pyridinium p-toluenesulfonate; 2-methoxypropene / CH₂Cl₂ / 0.05 h / 20 °C

17.1: 80 percent / lithium diisopropyl amide; MoO₅*pyridine*HMPA / tetrahydrofuran / 0.92 h / -23 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; methanol; N-chloro-succinimide; lithium aluminium tetrahydride; samarium diiodide; oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; carbon tetrabromide; 2-Methoxypropene; tetrabutyl ammonium fluoride; dihydrogen peroxide; 2,6-di-tert-butyl-4-hydroxytoluene; pyridinium p-toluenesulfonate; potassium hydride; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium carbonate; Dess-Martin periodane; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; ethyl acetate; acetone; benzene; 1.1: silylation / 2.1: Reduction / 3.1: Reduction / 4.1: Cyclization / 5.1: Ring cleavage / 6.1: Ring cleavage / 7.1: desilylation / 7.2: Isomerization / 8.1: cyclocondensation / 9.1: silylation / 10.1: Ring cleavage / 11.1: Dess-Martin oxidation / 12.1: Addition / 13.1: Metallation / 13.2: Condensation / 14.1: Condensation / 15.1: Chlorination / 16.1: Elimination / 17.1: hydroxylation;
DOI:10.1021/ja9939439