(+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Base Information

Chemical Name:(+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide
CAS No.:1200446-04-3
Molecular Formula:C₂₇H₂₇F₃N₄O₃S
Molecular Weight:544.598
Hs Code.:

Synonyms:(+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Suppliers and Price of (+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

There total 9 articles about (+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1276687-43-4
methyl (+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

: 1200446-04-3
(+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Guidance literature:: With ammonia; In methanol; at 70 ℃; for 48h;
DOI:10.1021/jm1011726

Reference yield:

: 5118-06-9
methyl 3-hydroxy-2-thiophenecarboxylate

: 1200446-04-3
(+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid; nitric acid / 3 h / -10 - 0 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

3: iron; acetic acid / 2 h / 65 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

5: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

6: trifluoroacetic acid / dichloromethane / 0 - 20 °C

7: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

8: formic acid / water / 85 °C

9: ammonia / methanol / 48 h / 70 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; formic acid; di-tert-butyl-diazodicarboxylate; sulfuric acid; ammonia; hydrogen; nitric acid; pyridinium p-toluenesulfonate; iron; caesium carbonate; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 2: Mitsunobu reaction / 4: Buchwald-Hartwig reaction / 7: Mitsunobu reaction;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-28-5
methyl (+/-)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

: 1200446-04-3
(+/-)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

4: formic acid / water / 85 °C

5: ammonia / methanol / 48 h / 70 °C

With formic acid; di-tert-butyl-diazodicarboxylate; ammonia; hydrogen; pyridinium p-toluenesulfonate; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; 3: Mitsunobu reaction;
DOI:10.1021/jm1011726