(1R,2S)-2-phenyl-1-cyclohexyl crotonate

Base Information

• Chemical Name: (1R,2S)-2-phenyl-1-cyclohexyl crotonate
• CAS No.: 143843-05-4
• Molecular Formula: C₁₆H₂₀O₂
• Molecular Weight: 244.334
• Mol file: 143843-05-4.mol

Synonyms:(1R,2S)-2-phenyl-1-cyclohexyl crotonate

Chemical Property of (1R,2S)-2-phenyl-1-cyclohexyl crotonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-phenyl-1-cyclohexyl crotonate

There total 1 articles about (1R,2S)-2-phenyl-1-cyclohexyl crotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trans-chrotonyl chloride (625-35-4,3488-22-0,10487-71-5) + (1R,2S)-trans-2-phenylcyclohexanol (98919-68-7) → (1R,2S)-2-phenyl-1-cyclohexyl crotonate (143843-05-4)

Guidance literature:

With silver cyanide; In toluene; for 7h; Heating;

DOI:10.1021/jm00100a031

Reference yield:

(1R,2S)-2-phenyl-1-cyclohexyl crotonate (143843-05-4) → (1R,2S)-2-phenyl-1-cyclohexyl<(triisopropylsilyl)oxy>acetate (132127-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) O₃, 2.) Me₂S, 3.) NaBH₄

2: 98 percent / imidazole / dimethylformamide / 36 h

With 1H-imidazole; sodium tetrahydroborate; dimethylsulfide; ozone; In N,N-dimethyl-formamide;

DOI:10.1021/jm00100a031

Reference yield:

(1R,2S)-2-phenyl-1-cyclohexyl crotonate (143843-05-4) → (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate (143843-06-5)

Guidance literature:

With sodium tetrahydroborate; dimethylsulfide; ozone; Yield given. Multistep reaction;

DOI:10.1021/jm00100a031

upstream raw materials:

trans-chrotonyl chloride

(1R,2S)-trans-2-phenylcyclohexanol

Downstream raw materials:

(-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate

(1R,2S)-2-phenyl-1-cyclohexyl<(triisopropylsilyl)oxy>acetate