(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

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Chemical Name:(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester
CAS No.:1039340-50-5
Molecular Formula:C₃₁H₃₆N₂O₅
Molecular Weight:516.637
Hs Code.:

Synonyms:(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

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Technology Process of (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

There total 1 articles about (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1039340-52-7
2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-ol

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1039340-49-2
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (S)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

: 1039340-50-5
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol800982n

Reference yield: 88.0%

: 1039340-50-5
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid (R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-yl ester

: 1039340-51-6
(R)-2-(hydroxy-diphenyl-methyl)-pyrrolidin-1-ol

Guidance literature:: With methanol; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ol800982n