(E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne

Base Information

• Chemical Name: (E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne
• CAS No.: 1189125-42-5
• Molecular Formula: C₁₈H₂₆O₂Si
• Molecular Weight: 302.489
• Mol file: 1189125-42-5.mol

Synonyms:(E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne

Chemical Property of (E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne

There total 2 articles about (E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(Z)-1-(4-methoxybenzyloxy)pent-3-en-2-yl pyridine-2-carboxylate (1189125-57-2) + trimethylsilylacetylene (1066-54-2) → (E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne (1189125-42-5)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

With copper(I) bromide dimethylsulfide complex; magnesium bromide; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

(Z)-1-(4-methoxybenzyloxy)pent-3-en-2-yl pyridine-2-carboxylate; In tetrahydrofuran; hexane; at 0 ℃; for 1h; regioselective reaction;

DOI:10.1021/jo901728b

Reference yield:

C19H21NO4 (1189125-41-4) + trimethylsilylacetylene (1066-54-2) → C18H26O2Si (1189125-53-8) + (E)-6-(4-methoxybenzyloxy)-3-methyl-1-(trimethylsilyl)hex-4-en-1-yne (1189125-42-5)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

With copper(I) bromide dimethylsulfide complex; magnesium bromide; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

C₁₉H₂₁NO₄; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

DOI:10.1021/jo901728b

upstream raw materials:

(Z)-1-(4-methoxybenzyloxy)pent-3-en-2-yl pyridine-2-carboxylate

trimethylsilylacetylene

C₁₉H₂₁NO₄