Technology Process of rac-8-(3,4-dimethoxybenzyl)-7,8-dihydroimidazo[1,2-a]pyrazin-6-one
There total 5 articles about rac-8-(3,4-dimethoxybenzyl)-7,8-dihydroimidazo[1,2-a]pyrazin-6-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: borane-THF / tetrahydrofuran / 0 - 60 °C
1.2: 0.5 h / 0 °C
2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -60 °C
3.2: -60 - 20 °C
4.1: ammonium hydroxide / water; methanol / 20 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
6.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C
6.2: 20 - 40 °C
With
hydrogenchloride; ammonium hydroxide; borane-THF; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
{2-[rac-1-tert-butoxycarbonylamino-2-(3,4-dimethoxyphenyl)ethyl]imidazol-1-yl}acetic acid methyl ester;
With
hydrogenchloride;
In
1,4-dioxane;
at 0 - 20 ℃;
With
triethylamine;
In
dichloromethane;
at 20 - 40 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -60 °C
1.2: -60 - 20 °C
2.1: ammonium hydroxide / water; methanol / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C
4.2: 20 - 40 °C
With
hydrogenchloride; ammonium hydroxide; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
