2,1-Benzisoxazole,6-chloro-(8CI,9CI)

Base Information

• Chemical Name: 2,1-Benzisoxazole,6-chloro-(8CI,9CI)
• CAS No.: 14313-60-1
• Molecular Formula: C7H4 Cl N O
• Molecular Weight: 153.568
• Hs Code.: 2934999090
• Mol file: 14313-60-1.mol

Synonyms:6-Chloroanthranil

Chemical Property of 2,1-Benzisoxazole,6-chloro-(8CI,9CI)

Chemical Property:

• Melting Point: 61.5-62 °C
• Boiling Point: 257.5±13.0 °C(Predicted)
• PKA: -3.97±0.30(Predicted)
• PSA: 26.03000
• Density: 1.377±0.06 g/cm3(Predicted)
• LogP: 2.48120
• Storage Temp.: 2-8°C

Purity/Quality:

6-Chlorobenzo[c]isoxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,1-Benzisoxazole,6-chloro-(8CI,9CI)

There total 3 articles about 2,1-Benzisoxazole,6-chloro-(8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Chloro-2-nitrobenzaldehyde (5551-11-1) → 6-chlorobenzo[c]isoxazole? (14313-60-1)

Guidance literature:

With tin(II) chloride dihdyrate; In methanol; ethyl acetate; at 25 ℃; for 20h;

DOI:10.1016/j.tetlet.2012.07.006

Reference yield:

C7H6ClNO3 → 6-chlorobenzo[c]isoxazole? (14313-60-1)

Guidance literature:

With tin(II) chloride dihdyrate; In methanol; ethyl acetate; at 20 ℃; for 24h;

DOI:10.1039/d1ob00468a

Reference yield:

→ 6-chlorobenzo[c]isoxazole? (14313-60-1)

Guidance literature:

4-Chlor-2-nitrobenzaldehyd, Sn-Folie/Eg.;

DOI:10.1016/S0040-4020(01)99094-5

upstream raw materials:

4-Chloro-2-nitrobenzaldehyde

Downstream raw materials:

1-(benzo[c]isoxazol-3-yl)hexan-1-one

6-chloro-3-phenylquinolin-2(1H)-one

3-chloroacridin-9(10H)-one

Refernces

• 1、 Liu, Jian-Li,Xu, Ren-Rui,Wang, Wei,Qi, Xinxin,Wu, Xiao-Feng. "Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1: H)-ones". supporting information. p. 3584 - 3588. Retrieved 2021/05/04.
• 2、 Zhuang, Shi-Yi,Tang, Yong-Xing,Chen, Xiang-Long,Wu, Yan-Dong,Wu, An-Xin. "I2-DMSO mediated oxidative amidation of methyl ketones with anthranils for the synthesis of: α -ketoamides". supporting information. p. 4258 - 4262. Retrieved 2021/05/31.