1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione
• CAS No.: 95969-67-8
• Molecular Formula: C₁₈H₁₉F₃N₂O₆
• Molecular Weight: 416.354

Synonyms:1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-benzoyl-2'-deoxy-5'-O-(4-methoxybenzyl)-5-trifluoromethyluridine → 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione (95969-67-8)

Guidance literature:

With ammonium hydroxide; In ethanol; acetone; Ambient temperature;

DOI:10.1021/jm00121a025

Reference yield:

p-Methoxybenzyl bromide (2746-25-0) → 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione (95969-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: silver oxide / butan-2-one / Heating

2: 43 percent / 30percent NH₄OH / ethanol; acetone / Ambient temperature

With ammonium hydroxide; silver(l) oxide; In ethanol; acetone; butanone;

DOI:10.1021/jm00121a025

Reference yield:

N3-benzoyl-2'-deoxy-5-(trifluoromethyl)uridine (95969-47-4) → 1-[(2R,4S,5R)-4-Hydroxy-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-5-trifluoromethyl-1H-pyrimidine-2,4-dione (95969-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: silver oxide / butan-2-one / Heating

2: 43 percent / 30percent NH₄OH / ethanol; acetone / Ambient temperature

With ammonium hydroxide; silver(l) oxide; In ethanol; acetone; butanone;

DOI:10.1021/jm00121a025

upstream raw materials:

p-Methoxybenzyl bromide

N³-benzoyl-2'-deoxy-5-(trifluoromethyl)uridine

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