(S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

Base Information

Chemical Name:(S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester
CAS No.:1322746-32-6
Molecular Formula:C₂₃H₃₃N₃O₈
Molecular Weight:479.53
Hs Code.:

Synonyms:(S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

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Chemical Property of (S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

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Technology Process of (S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

There total 5 articles about (S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1322746-31-5
(S)-2-tert-butyloxycarbonylamino-4-(piperidin-4-yl)butanoic acid methyl ester

: 4457-32-3
4-nitrobenzyl chloroformate

: 1322746-32-6
(S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h; pH=8 - 9;

Reference yield:

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 1322746-32-6
(S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0.33 h / -78 °C

1.2: -78 - 0 °C

2.1: hydrogen / (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / methanol / 18.5 h / 20 °C / 3000.3 Torr / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C / pH 8 - 9

With hydrogen; triethylamine; N,N,N',N'-tetramethylguanidine; (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 130312-10-6
benzyl 4-(2-oxoethyl)piperidine-1-carboxylate

: 1322746-32-6
(S)-2-tert-butyloxycarbonylamino-4-(1-(4-nitrobenzyloxy)carbonylpiperidin-4-yl)butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0.33 h / -78 °C

1.2: -78 - 0 °C

2.1: hydrogen / (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / methanol / 18.5 h / 20 °C / 3000.3 Torr / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C / pH 8 - 9

With hydrogen; triethylamine; N,N,N',N'-tetramethylguanidine; (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol;