Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide

Base Information

• Chemical Name: Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide
• CAS No.: 900143-78-4
• Molecular Formula: C₁₆H₂₅NO₃S
• Molecular Weight: 311.445
• Mol file: 900143-78-4.mol

Synonyms:Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide

Chemical Property of Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide

There total 1 articles about Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-benzylpropane-1-sulfonamide (207574-06-9) + (R)-2-(but-3-en-1-yl)oxirane (137688-20-1) → Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide (900143-78-4)

Guidance literature:

tetraethylammonium chloride; potassium carbonate; In 1,4-dioxane; at 100 ℃;

DOI:10.1016/j.tetlet.2006.04.038

Reference yield:

Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide (900143-78-4) → (4S,5R)-2-Benzyl-4-but-3-enyl-5-ethyl-isothiazolidine 1,1-dioxide

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / DMAP / 50 °C

2: n-BuLi / tetrahydrofuran / 2 h / -78 - 20 °C

With pyridine; n-butyllithium; dmap; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.04.038

Reference yield:

Propane-1-sulfonic acid benzyl-((R)-2-hydroxy-hex-5-enyl)-amide (900143-78-4) → (4S,5S)-2-Benzyl-4-but-3-enyl-5-ethyl-isothiazolidine 1,1-dioxide

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / DMAP / 50 °C

2: n-BuLi / tetrahydrofuran / 2 h / -78 - 20 °C

With pyridine; n-butyllithium; dmap; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.04.038

upstream raw materials:

N-benzylpropane-1-sulfonamide

(R)-2-(but-3-en-1-yl)oxirane