5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride

Base Information

• Chemical Name: 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride
• CAS No.: 1181814-94-7
• Molecular Formula: C₁₁H₁₁N₃O₃*ClH
• Molecular Weight: 269.688

Synonyms:5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride

Chemical Property of 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride

Chemical Property:

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Technology Process of 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride

There total 1 articles about 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-tert-butoxycarbonylaminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester (1181814-92-5) → 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride (1181814-94-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jm9009229

Reference yield:

5-methylfurfurylamine (14003-16-8) + 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride (1181814-94-7) → 5-(2-aminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid (5-methylfuran-2-ylmethyl)amide (1181815-01-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 88 ℃; Inert atmosphere;

DOI:10.1021/jm9009229

Reference yield:

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 5-(2-amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester hydrochloride (1181814-94-7) → 5-(2-aminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid (2-(morpholin-4-yl)ethyl)amide (1181814-71-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 88 ℃; Inert atmosphere;

DOI:10.1021/jm9009229

upstream raw materials:

5-(2-tert-butoxycarbonylaminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Downstream raw materials:

5-(2-aminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid 3-fluoro-4-trifluoromethylbenzylamide

5-(2-aminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid (2-(morpholin-4-yl)ethyl)amide

5-(2-aminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid (3-imidazol-1-ylpropyl)amide

5-(2-aminophenyl)-[1,3,4]oxadiazole-2-carboxylic acid [3-(2-oxopyrrolidin-1-yl)propyl]amide

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