Technology Process of 4-(6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(2-(isopropylamino)ethoxy)pyridin-2-yl)-N,N,3-trimethylbenzamide
There total 11 articles about 4-(6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(2-(isopropylamino)ethoxy)pyridin-2-yl)-N,N,3-trimethylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dimethyl sulfoxide;
at 40 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 20 h / 60 °C / Inert atmosphere
2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C
3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; ethanol / 15 h / 80 °C / Inert atmosphere; Sealed tube
4.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 17 h / 120 °C / Sealed tube
5.1: phosphorus tribromide / N,N-dimethyl-formamide / 8 h / 0 - 80 °C / Inert atmosphere
6.1: dimethyl sulfoxide / 16 h / 40 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 2-iodoxybenzoic acid; phosphorus tribromide; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite;
In
ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
2.2: 20 h / 60 °C / Inert atmosphere
3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C
4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; ethanol / 15 h / 80 °C / Inert atmosphere; Sealed tube
5.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 17 h / 120 °C / Sealed tube
6.1: phosphorus tribromide / N,N-dimethyl-formamide / 8 h / 0 - 80 °C / Inert atmosphere
7.1: dimethyl sulfoxide / 16 h / 40 °C / Inert atmosphere
With
ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium(0); 2-iodoxybenzoic acid; phosphorus tribromide; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide;
In
ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
