4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

Base Information

Chemical Name:4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester
CAS No.:1027173-03-0
Molecular Formula:C₂₂H₁₇BrN₂O₂
Molecular Weight:421.293
Hs Code.:

Synonyms:4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

There total 6 articles about 4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027985-23-4
N-{2-[(4-Bromo-phenyl)-methyl-amino]-phenyl}-terephthalamic acid methyl ester

: 1027173-03-0
4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

Guidance literature:: With PPA; In dichloromethane; at 110 ℃; for 2h;
DOI:10.1021/jm9704309

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1027173-03-0
4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate, copper iodide / xylene / 19 h / 150 °C

2: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 1 h

3: H₂ / 10percent Pd/C / ethanol / 4 h / 40 °C

4: pyridine / benzene / 24 h

5: polyphosphoric acid / CH₂Cl₂ / 2 h / 110 °C

With pyridine; copper(l) iodide; PPA; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; xylene; benzene;
DOI:10.1021/jm9704309

Reference yield:

: 58476-59-8
4-bromo-N-(2-nitrophenyl)benzenamine

: 1027173-03-0
4-(2-Bromo-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 1 h

2: H₂ / 10percent Pd/C / ethanol / 4 h / 40 °C

3: pyridine / benzene / 24 h

4: polyphosphoric acid / CH₂Cl₂ / 2 h / 110 °C

With pyridine; PPA; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm9704309