1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

Base Information

Chemical Name:1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine
CAS No.:1097921-45-3
Molecular Formula:C₁₉H₃₀N₄O₃
Molecular Weight:362.472
Hs Code.:

Synonyms:1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

Suppliers and Price of 1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

There total 1 articles about 1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 109-01-3
1-methyl-piperazine

: 28987-46-4
4-fluoro-1-nitro-2-(propan-2-yloxy)benzene

: 41979-39-9
4-piperidone hydrochloride

: 1097921-45-3
1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

Guidance literature:: 4-fluoro-1-nitro-2-(propan-2-yloxy)benzene; 4-piperidone hydrochloride; With potassium carbonate; In N,N-dimethyl-formamide; Heating;

1-methyl-piperazine; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; at 20 ℃;
DOI:10.1248/cpb.c17-00784

Reference yield:

: 1097921-45-3
1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

: 1097921-48-6
4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-(propan-2-yloxy)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 8h; under 760.051 Torr;
DOI:10.1248/cpb.c17-00784

Reference yield:

: 1097921-45-3
1-methyl-4-{1-[4-nitro-3-(propan-2-yloxy)phenyl]piperidin-4-yl}piperazine

: 1097918-72-3
N-{4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-(propan-2-yloxy)phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 8 h / 20 °C / 760.05 Torr

2.1: methanesulfonic acid / ethanol / 0.25 h / 20 °C

2.2: 2 h / Heating

With methanesulfonic acid; palladium 10% on activated carbon; hydrogen; In ethanol;
DOI:10.1248/cpb.c17-00784