[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

Base Information

Chemical Name:[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate
CAS No.:1083092-36-7
Molecular Formula:C₃₆H₄₇ClN₆O₇S₂
Molecular Weight:775.39
Hs Code.:

[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

Synonyms:[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

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Chemical Property of [(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

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Technology Process of [(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

There total 12 articles about [(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 3400-56-4
α-bromobutyraldehyde diethyl acetal

: 1083092-39-0
[(3R,5S)-5-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-thioureidoacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

: 1083092-36-7
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 100 ℃; for 16h;

Reference yield:

: 159622-10-3,213316-50-8,259221-77-7
(1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid

: 1083092-36-7
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / palladium hydroxide on carbon / tert-butyl methyl ether / 5 h / 20 °C / 760.05 Torr

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 - 60 °C

2.2: 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

4.2: pH 3 - 4

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

8.1: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

8.2: 1 h

8.3: 2 h / 20 °C

9.1: sodium hydrogencarbonate / ethanol / 16 h / 100 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-carbonyldiimidazole; palladium hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 923590-72-1
1-tert-butyl 2-methyl (2S,4R)-4-{[(4-chloro-1,3-dihydro-2H-isoindol-2-yl)carbonyl]oxy}pyrrolidine-1,2-dicarboxylate

: 1083092-36-7
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-cyclohexyl-2-(5-ethylthiazol-2-ylamino)acetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol; lithium hydroxide; water / tetrahydrofuran / 20 °C

1.2: pH ~ 2

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

2.2: pH 3 - 4

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

6.2: 1 h

6.3: 2 h / 20 °C

7.1: sodium hydrogencarbonate / ethanol / 16 h / 100 °C

With hydrogenchloride; methanol; lithium hydroxide; water; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;