N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

Base Information

• Chemical Name: N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine
• CAS No.: 130985-44-3
• Molecular Formula: C₆₀H₈₇N₉O₁₀S
• Molecular Weight: 1126.47

Synonyms:N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property of N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

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Technology Process of N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

There total 5 articles about N-α--L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-[(tert-butoxycarbonyl)amino]-3-methylbutanoic acid (129765-95-3) + (2S,4S,5S)-5-{(S)-2-[((S)-2-Amino-3-phenyl-propionyl)-methyl-amino]-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid [(1S,2S)-2-methyl-1-(methyl-pyridin-2-yl-carbamoyl)-butyl]-amide → N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-44-3)

Guidance literature:

With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

DOI:10.1021/jm00106a026

Reference yield:

ethyl 3-amino-3-methylbutanoate (85532-42-9) → N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / CH₂Cl₂ / 18 h

2: 82 percent / aq. KOH / tetrahydrofuran / 18 h

3: 100 percent / diisopropylethylamine, diethylphosphorocyanate / CH₂Cl₂ / 18 h

With potassium hydroxide; diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00106a026

Reference yield:

ethyl 3-methylbut-2-enoate (638-10-8) → N-α--L-phenylalanyl>-Nα-methyl-Nim-tosyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-44-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / NH₃(gas) / ethanol / 22 h / 80 °C

2: 81 percent / CH₂Cl₂ / 18 h

3: 82 percent / aq. KOH / tetrahydrofuran / 18 h

4: 100 percent / diisopropylethylamine, diethylphosphorocyanate / CH₂Cl₂ / 18 h

With potassium hydroxide; diethyl cyanophosphonate; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00106a026

upstream raw materials:

3-[(tert-butoxycarbonyl)amino]-3-methylbutanoic acid

ethyl 3-methylbut-2-enoate

ethyl 3-amino-3-methylbutanoate

ethyl 3-<(butyloxycarbonyl)amino>-3-methylbutanoate

Downstream raw materials:

N-α-(β-L-valyl-L-phenylalanyl)-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine tris(trifluoroacetate)

N-α-(β-L-valyl)-L-phenylalanyl-N^α-methyl-L-histidyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine tris(trifluoroacetate)

N-α--L-phenylalanyl>-N^α-methyl-L-histidyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>(1-oxo-2-pyridyl)methylamine

N-α--L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanoyl>-L-isoleucyl>-2-pyridylmethylamine

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