(2S)-3-(Benzyloxy)-2-azido-1-propanol

Base Information

Chemical Name:(2S)-3-(Benzyloxy)-2-azido-1-propanol
CAS No.:242812-38-0
Molecular Formula:C₁₀H₁₃N₃O₂
Molecular Weight:207.232
Hs Code.:
DSSTox Substance ID:DTXSID001270290
Nikkaji Number:J525.403E

Synonyms:DTXSID001270290;(2S)-3-(Benzyloxy)-2-azido-1-propanol;(2S)-2-Azido-3-(phenylmethoxy)-1-propanol;242812-38-0

Suppliers and Price of (2S)-3-(Benzyloxy)-2-azido-1-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-3-(Benzyloxy)-2-azido-1-propanol

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:207.100776666
Heavy Atom Count:15
Complexity:211

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COCC(CO)N=[N+]=[N-]
Isomeric SMILES:C1=CC=C(C=C1)COC[C@H](CO)N=[N+]=[N-]

Technology Process of (2S)-3-(Benzyloxy)-2-azido-1-propanol

There total 2 articles about (2S)-3-(Benzyloxy)-2-azido-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-Benzyloxymethyl-2,2,2-triphenyl-2λ⁵-[1,3,2]dioxaphospholane

: 131065-11-7
(R)-3-azido-1-O-benzyl-1,2-propanediol

: 242812-38-0
(S)-2-azido-3-O-benzyl-1,3-propanediol

Guidance literature:: (S)-4-Benzyloxymethyl-2,2,2-triphenyl-2λ⁵-[1,3,2]dioxaphospholane; With trimethylsilylazide; In tetrahydrofuran; at 0 - 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo9906375

Reference yield:

: 56552-80-8
(R)-3-benzyloxy-1,2-propanediol

: 242812-38-0
(S)-2-azido-3-O-benzyl-1,3-propanediol

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 °C

2.1: Me₃SiN₃ / tetrahydrofuran / 0 - 20 °C

2.2: TBAF / tetrahydrofuran / 20 °C

With trimethylsilylazide; di-isopropyl azodicarboxylate; In tetrahydrofuran; 1.1: Cycloaddition / 2.1: silylation; azidation / 2.2: desilylation;
DOI:10.1021/jo9906375

Reference yield: 89.0%

: 1004537-62-5
C₂₄H₄₂O₅S

: 242812-38-0
(S)-2-azido-3-O-benzyl-1,3-propanediol

: 1071838-72-6
C₃₃H₅₁N₃O₄

Guidance literature:: (S)-2-azido-3-O-benzyl-1,3-propanediol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

C₂₄H₄₂O₅S; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1021/jo801666t