5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

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Chemical Name:5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone
CAS No.:1270000-16-2
Molecular Formula:C₃₀H₂₆N₄O₅S
Molecular Weight:554.626
Hs Code.:

Synonyms:5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

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Chemical Property of 5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

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Technology Process of 5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

There total 5 articles about 5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270000-15-1
5-((1-ethyl-5-hydroxy-1H-pyrazol-4-yl)carbonyl)-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

: 98-59-9
p-toluenesulfonyl chloride

: 1270000-16-2
5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 72h;

Reference yield:

: 100-46-9
benzylamine

: 1270000-16-2
5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 24 h / 65 °C

2.1: ethanol / 24 h / Reflux

3.1: pyridine; lithium iodide / 76 h / 20 °C / Reflux

3.2: pH 7

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

4.2: 0.5 h / 20 °C

5.1: triethylamine / 2-hydroxy-2-methylpropanenitrile / acetonitrile / 24 h / 20 °C

6.1: triethylamine / acetonitrile / 72 h / 20 °C

With pyridine; oxalyl dichloride; triethylamine; lithium iodide; N,N-dimethyl-formamide; 2-hydroxy-2-methylpropanenitrile; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 5333-86-8
ethyl benzimidate hydrochloride

: 1270000-16-2
5-[[1-ethyl-5-[[(4-methylphenyl)sulfonyl]oxy]-1H-pyrazol-4-yl]carbonyl]-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 24 h / 65 °C

2.1: ethanol / 24 h / Reflux

3.1: pyridine; lithium iodide / 76 h / 20 °C / Reflux

3.2: pH 7

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

4.2: 0.5 h / 20 °C

5.1: triethylamine / 2-hydroxy-2-methylpropanenitrile / acetonitrile / 24 h / 20 °C

6.1: triethylamine / acetonitrile / 72 h / 20 °C

With pyridine; oxalyl dichloride; triethylamine; lithium iodide; N,N-dimethyl-formamide; 2-hydroxy-2-methylpropanenitrile; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;