4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

Base Information

Chemical Name:4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride
CAS No.:950606-92-5
Molecular Formula:C₁₉H₂₀BrN₃S*ClH
Molecular Weight:438.819
Hs Code.:

Synonyms:4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

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Chemical Property of 4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

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Technology Process of 4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

There total 5 articles about 4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 950605-56-8
2-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-1,3,4-oxadiazole

: 100-46-9
benzylamine

: 950606-92-5
4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

Guidance literature:: 2-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-1,3,4-oxadiazole; benzylamine; With acetic acid; at 170 ℃; Microwave irradiation;

With hydrogenchloride; In ethyl acetate;
DOI:10.1248/cpb.c19-00211

Reference yield:

: 880166-34-7
2-methyl-2-(thiophen-2-yl)-propanehydrazide

: 950606-92-5
4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 °C / Cooling with ice

2: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 72 h / 20 °C / Cooling with ice

3: acetic acid; N-Bromosuccinimide / 20 °C

4: acetic acid / 170 °C / Microwave irradiation

With pyridine; N-Bromosuccinimide; trifluoromethylsulfonic anhydride; acetic acid; triethylamine; In dichloromethane;
DOI:10.1248/cpb.c19-00211

Reference yield:

: 950605-40-0
N'-[2-methyl-2-(thiophen-2-yl)propanoyl]cyclopropanecarbohydrazide

: 950606-92-5
4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 72 h / 20 °C / Cooling with ice

2: acetic acid; N-Bromosuccinimide / 20 °C

3: acetic acid / 170 °C / Microwave irradiation

With pyridine; N-Bromosuccinimide; trifluoromethylsulfonic anhydride; acetic acid; In dichloromethane;
DOI:10.1248/cpb.c19-00211