2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

Base Information

Chemical Name:2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide
CAS No.:1616059-35-8
Molecular Formula:C₂₁H₂₇N₃O₅S
Molecular Weight:433.528
Hs Code.:

Synonyms:2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

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Chemical Property of 2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

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Technology Process of 2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

There total 7 articles about 2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 933713-75-8
1-amino-3-(isoindolin-2-yl)propan-2-ol

: 1616059-84-7
ethyl 2-(2-(N,N-dimethylsulfamoyl)phenoxy)acetate

: 1616059-35-8
2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

Guidance literature:: In ethanol; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 21942-58-5
2-(oxiran-2-ylmethyl)isoindoline

: 1616059-35-8
2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / ethanol / 4 h / 80 °C

2: ethanol / 0.5 h / 120 °C / Microwave irradiation

With ammonia; In ethanol;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1616059-35-8
2-(2-(N,N-dimethylsulfamoyl)phenoxy)-N-(2-hydroxy-3-(isoindolin-2-yl)propyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 4 h / 80 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

3: acetic acid; water; 1,3-dichloro-5,5-dimethylhydantoin / acetonitrile / 3 h / 0 °C

4: pyridine / 16 h / 0 - 25 °C

5: ethanol / 0.5 h / 120 °C / Microwave irradiation

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-dichloro-5,5-dimethylhydantoin; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; acetonitrile;