N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Base Information

• Chemical Name: N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)
• CAS No.: 304849-88-5
• Molecular Formula: C₅₄H₆₀N₅O₉P
• Molecular Weight: 954.072

Synonyms:N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Chemical Property of N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

There total 12 articles about N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + N4-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (304849-86-3) → N4-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) (304849-88-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N4-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) (304849-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / DMAP / pyridine / 3 h / 20 °C

2: 91 percent / iPr₂EtN / tetrahydrofuran / 1 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; 1: Etherification / 2: Substitution;

DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8

Reference yield:

5-[(benzyloxy)methyl]uridine (24751-66-4) → N4-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) (304849-88-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 78 percent / pyridine / 18 h / 20 °C

2.1: DMAP / acetonitrile / 18 h / 20 °C

3.1: Bu₃SnH; AIBN / toluene / 2.5 h / 80 °C

4.1: 1,2,4-1H-triazole; POCl₃; Et₃N / acetonitrile / 0.67 h / 20 °C

4.2: 87 percent / aq. NH₃ / dioxane / 0.5 h / 20 °C

5.1: 90 percent / pyridine / 15 h / 0 - 20 °C

6.1: 91 percent / Bu₄NF*3H₂O / tetrahydrofuran / 0.5 h / 20 °C

7.1: 88 percent / DMAP / pyridine / 3 h / 20 °C

8.1: 91 percent / iPr₂EtN / tetrahydrofuran / 1 h / 20 °C

With 1,2,4-Triazole; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; pyridine; toluene; acetonitrile; 1.1: Substitution / 2.1: Substitution / 3.1: Reduction / 4.1: Substitution / 4.2: Substitution / 5.1: Acylation / 6.1: Substitution / 7.1: Etherification / 8.1: Substitution;

DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

4,4'-dimethoxytrityl chloride

5-[(benzyloxy)methyl]uridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 304849-88-5 N⁴-benzoyl-5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Send

Send

Metric Ton KG G Pound L ML

Send

Send