5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

Base Information

Chemical Name:5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one
CAS No.:860032-39-9
Molecular Formula:C₄₁H₅₂N₄O₄Si
Molecular Weight:692.974
Hs Code.:

Synonyms:5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

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Chemical Property of 5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

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Technology Process of 5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

There total 1 articles about 5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 206559-44-6
5-bromo-2-methoxyphenethylamine hydrobromide

: 530118-80-0
5-{(R)-2-[2-(4-amino-phenyl)-ethylamino]-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

: 860032-39-9
5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

Guidance literature:: 5-bromo-2-methoxyphenethylamine hydrobromide; 5-{(R)-2-[2-(4-amino-phenyl)-ethylamino]-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one; With sodium t-butanolate; In toluene; at 90 ℃;

tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 90 ℃; for 5h;

Reference yield:

: 860032-39-9
5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

: 5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-hydroxy-ethyl]-8-benzyloxy-1H-quinolin-2-one trifluoroacetate

Guidance literature:: 5-[(R)-2-(2-{4-[3-(2-amino-ethyl)-4-methoxy-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one; With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; for 5h;

With trifluoroacetic acid;