(1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Base Information

Chemical Name:(1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate
CAS No.:922705-75-7
Molecular Formula:C₁₆H₁₉N₃O₅
Molecular Weight:333.344
Hs Code.:

Synonyms:(1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Suppliers and Price of (1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

There total 3 articles about (1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 519156-37-7
(2S,3R)-3-(acetyloxy)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)butanoic acid

: 922705-75-7
(1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Guidance literature:: (2S,3R)-3-(acetyloxy)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)butanoic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at -15 ℃; for 0.25h;

diazomethane; In tetrahydrofuran; dichloromethane; at -15 - 20 ℃;
DOI:10.1002/hlca.200690235

Reference yield:

: 22839-46-9
(2S,3R)-3-acetoxy-2-((benzyloxycarbonyl)amino)-butanoic acid

: 922705-75-7
(1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CSA / toluene / Heating

2.1: Et₃SiH; CF₃COOH / CH₂Cl₂

3.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3.2: 60 percent / tetrahydrofuran; CH₂Cl₂ / -15 - 20 °C

With 4-methyl-morpholine; triethylsilane; chloroformic acid ethyl ester; trifluoroacetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/hlca.200690235

Reference yield:

: 519156-34-4
phenylmethyl (4S)-4-[(1R)-1-(acetyloxy)ethyl]-5-oxo-1,3-oxazolidine-3-carboxylate

: 922705-75-7
(1R,2S)-4-diazo-1-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-3-oxobutyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃SiH; CF₃COOH / CH₂Cl₂

2.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

2.2: 60 percent / tetrahydrofuran; CH₂Cl₂ / -15 - 20 °C

With 4-methyl-morpholine; triethylsilane; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200690235