2-(4-Methylpiperidin-1-yl)ethanamine

Base Information

• Chemical Name: 2-(4-Methylpiperidin-1-yl)ethanamine
• CAS No.: 14156-95-7
• Molecular Formula: C8H18 N2
• Molecular Weight: 142.244
• Hs Code.: 2933399090
• European Community (EC) Number: 675-482-4
• DSSTox Substance ID: DTXSID90354822
• Wikidata: Q82133270
• Mol file: 14156-95-7.mol

Synonyms:2-(4-methylpiperidin-1-yl)ethanamine;14156-95-7;2-(4-Methyl-piperidin-1-yl)-ethylamine;2-(4-methyl-1-piperidinyl)ethanamine;1-piperidineethanamine, 4-methyl-;MFCD00129007;2-(4-methylpiperidin-1-yl)ethan-1-amine;2-(4-Methylpiperidin-1-yl)ethylamine;2-(4-methyl-1-piperidyl)ethanamine;n-aminoethyl 4-pipecoline;SCHEMBL242420;n-(2-aminoethyl)-4-pipecoline;DTXSID90354822;BTEYOILJVIONOI-UHFFFAOYSA-N;STR07561;2-(4-Methyl-1-piperidyl)ethylamine;BBL040381;STK350264;1-(2-aminoethyl)-4-methylpiperidine;AKOS000143105;SB41212;[2-(4-methylpiperidin-1-yl)ethyl]amine;SY037782;BB 0219891;CS-0206189;FT-0733841;EN300-40125;E84744;A925319;Z271005810

Chemical Property of 2-(4-Methylpiperidin-1-yl)ethanamine

Chemical Property:

• Vapor Pressure: 0.227mmHg at 25°C
• Refractive Index: 1.468
• Boiling Point: 207.3°C at 760 mmHg
• Flash Point: 74.4°C
• PSA: 29.26000
• Density: 0.895g/cm³
• LogP: 1.31520
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 142.146998583
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-methylpiperidin-1-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCN(CC1)CCN

Technology Process of 2-(4-Methylpiperidin-1-yl)ethanamine

There total 4 articles about 2-(4-Methylpiperidin-1-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

tert-butyl (2-(4-methylpiperidin-1-yl)ethyl)carbamate (689300-49-0) → 2-(4-methylpiperidin-1-yl)ethan-1-amine (14156-95-7)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.03.050

Reference yield:

4-methylpiperidin (626-58-4) → 2-(4-methylpiperidin-1-yl)ethan-1-amine (14156-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI; K₂CO₃ / acetonitrile

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; sodium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm049447z

Reference yield:

(4-methyl-piperidin-1-yl)-acetonitrile (847574-01-0) → 2-(4-methylpiperidin-1-yl)ethan-1-amine (14156-95-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm049447z

upstream raw materials:

(4-methyl-piperidin-1-yl)-acetonitrile

4-methylpiperidin

tert-butyl (2-(4-methylpiperidin-1-yl)ethyl)carbamate

Downstream raw materials:

(4-bromo-2-methyl-phenyl)-[2-(4-methyl-piperidin-1-yl)-ethyl]-amine

Refernces

• 1、 Ruchelman, Alexander L.,Houghton, Peter J.,Zhou, Nai,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.. "5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance". . p. 792 - 804. Retrieved 2007/10/03.