2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

Base Information

Chemical Name:2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione
CAS No.:252960-96-6
Molecular Formula:C₂₂H₁₈N₂O₅
Molecular Weight:390.395
Hs Code.:

Synonyms:2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

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Chemical Property of 2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

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Technology Process of 2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

There total 1 articles about 2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4756-92-7
3a,4,5,6-tetrahydrosuccinimido<3,4-b>acenaphthen-10-one

: 100-27-6
2-(4-nitrophenyl)ethanol

: 252960-96-6
2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/a903141c

Reference yield: 97.0%

: 252960-96-6
2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

: 2-(4-Aminophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;
DOI:10.1039/a903141c

Reference yield:

: 252960-96-6
2-(4-Nitrophenethyl)-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrole-1,3,4-trione

: 252960-71-7
Benzyl 5-[2-(1,3,4-trioxo-2,3,5,6,10,10a-hexahydro-1H,4H-acenaphtho[1,8a-c]pyrrolyl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / H₂; HCl / 10 percent Pd/C / aq. ethanol / 20 °C

2.1: NaNO₂; HCl / aq. ethanol / 0.5 h / 0 °C

2.2: 40 percent / AcONa*3H₂O / aq. ethanol / 0 - 15 °C

3.1: 25 percent / HCl / aq. ethanol / 24 h / Heating

4.1: 43 percent / Ti(i-PrO)4 / 18 h / 100 °C

With titanium(IV) isopropylate; hydrogenchloride; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; 1.1: Catalytic hydrogenation / 2.1: Diazotization / 2.2: Condensation / 3.1: Cyclization / 4.1: Transesterification;
DOI:10.1039/a903141c