Technology Process of N-(3-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,2-dimethylpropyl)benzamide
There total 4 articles about N-(3-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,2-dimethylpropyl)benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: boron tribromide / dichloromethane / 0.2 h / -78 °C
1.2: 0 °C
2.1: potassium nitrososulfonate / methanol; water; N,N-dimethyl-formamide / 10 h / 20 °C
With
potassium nitrososulfonate; boron tribromide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.020
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.08 h / 0 - 20 °C
1.2: 20 °C
2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 1 h / 20 °C
3.1: boron tribromide / dichloromethane / 0.2 h / -78 °C
3.2: 0 °C
4.1: potassium nitrososulfonate / methanol; water; N,N-dimethyl-formamide / 10 h / 20 °C
With
lithium aluminium tetrahydride; potassium nitrososulfonate; boron tribromide; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.020
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.08 h / 0 - 20 °C
2.2: 20 °C
3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 1 h / 20 °C
4.1: boron tribromide / dichloromethane / 0.2 h / -78 °C
4.2: 0 °C
5.1: potassium nitrososulfonate / methanol; water; N,N-dimethyl-formamide / 10 h / 20 °C
With
lithium aluminium tetrahydride; n-butyllithium; potassium nitrososulfonate; boron tribromide; diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.020
