((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

Base Information

Chemical Name:((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate
CAS No.:1248682-58-7
Molecular Formula:C₄₃H₃₈INO₆S
Molecular Weight:823.748
Hs Code.:

Synonyms:((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

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Chemical Property of ((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

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Technology Process of ((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

There total 1 articles about ((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 86-55-5
1-naphthalenecarboxylic acid

: 1248682-56-5
((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol

: 1248682-58-7
((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja1065202

Reference yield: 72.0%

: 1248681-99-3
4-(benzyloxy)-5-methoxy-7-((triisopropylsilyloxy)methyl)naphthalen-1-ylboronic acid

: 1248682-58-7
((1R,3S)-6,8-bis(benzyloxy)-5-iodo-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

: ((1R,3S,5R)-6,8-bis(benzyloxy)-5-(4-(benzyloxy)-5-methoxy-7-(((triisopropylsilyl)oxy)methyl)naphthalen-1-yl)-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl 1-naphthoate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium(II) iodide; In butan-1-ol; at 20 ℃; for 24h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja1065202