(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Base Information

Chemical Name:(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate
CAS No.:1379763-29-7
Molecular Formula:C₃₇H₅₃NO₇
Molecular Weight:623.83
Hs Code.:

Synonyms:(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Suppliers and Price of (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

There total 3 articles about (R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1379763-14-0
dineopentyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate

: 103-49-1
dibenzylamine

: 1379763-29-7
(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Guidance literature:: With nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃; In 1,2-dimethoxyethane; at 20 ℃; for 6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja302691r

Reference yield: 97.0%

: 1379763-14-0
dineopentyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate

: 189885-29-8
tert-butyl (E)-4-(benzylamino)-2-butenoate

: 1379763-29-7
(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Guidance literature:: With nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃; In 1,2-dimethoxyethane; at 20 ℃; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja302691r

Reference yield:

: 891485-88-4
Di-neopentyl-4'-methoxybenzalmalonate

: 1379763-29-7
(R,E)-dineopentyl 2-(2-(benzyl(4-tert-butoxy-4-oxobut-2-enyl)amino)-2-(4-methoxyphenyl)ethyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃ / 1,2-dimethoxyethane / 4 h / 20 °C / Inert atmosphere; Molecular sieve

With nickel(II) perchlorate hexahydrate; C₃₃H₂₉N₃O₃; sodium hydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja302691r