4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

Base Information

Chemical Name:4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride
CAS No.:1352307-40-4
Molecular Formula:C₃₀H₃₃NO₃*ClH
Molecular Weight:492.058
Hs Code.:

Synonyms:4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

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Chemical Property of 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

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Technology Process of 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

There total 13 articles about 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352308-00-9
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol

: 1352307-40-4
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;

Reference yield:

: C₃₅H₄₁NO₄

: 1352307-40-4
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

Guidance literature:: C₃₅H₄₁NO₄; With acetic acid; In water; at 20 ℃;

With hydrogenchloride;
DOI:10.1021/acs.jmedchem.8b00921

Reference yield:

: 2938-98-9,70423-38-0,101978-85-2,22644-28-6
(R)-2-methylbutane-1,4-diol

: 1352307-40-4
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-phenyl-2H-chromen-6-ol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.5 h / -20 - -15 °C

2: neat (no solvent) / 24 h / 20 °C

3: caesium carbonate; copper(l) iodide / 48 h / 125 °C / Inert atmosphere

4: acetic acid / water / 20 °C

With copper(l) iodide; caesium carbonate; acetic acid; triethylamine; In dichloromethane; water; 3: |Ullmann Condensation;
DOI:10.1021/acs.jmedchem.8b00921