1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

Base Information

Chemical Name:1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne
CAS No.:124267-07-8
Molecular Formula:C₂₃H₄₂O₂Si
Molecular Weight:378.671
Hs Code.:

Synonyms:1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

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Chemical Property of 1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

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Technology Process of 1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

There total 3 articles about 1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 432-25-7
2,6,6-trimethylcyclohex-1-enecarbaldehyde

: 119837-81-9
tert-butyl(hept-6-yn-1-yloxy)dimethylsilane

: 124267-07-8
1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/jo00289a059

Reference yield:

: 63478-76-2
1-hydroxy-6-heptyne

: 124267-07-8
1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 78 percent / n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00289a059

Reference yield:

: 14916-79-1
3-heptyn-1-ol

: 124267-07-8
1-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-1-hydroxy-8-(tert-butyldimethylsiloxy)-2-octyne

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / KAPA (potassium 1-aminopropylamide) / 1.5 h / Ambient temperature; sonicated

2: 85 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 78 percent / n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

With 1H-imidazole; n-butyllithium; potassium salt of 1,3-diaminopropane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00289a059