[5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester
CAS No.:113598-12-2
Molecular Formula:C₁₈H₁₄F₃NO₄
Molecular Weight:365.309
Hs Code.:

Synonyms:[5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

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Chemical Property of [5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

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Technology Process of [5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

There total 4 articles about [5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 113598-09-7
4-Furan-2-yl-4-oxo-3-(3-trifluoromethyl-benzoylamino)-butyric acid ethyl ester

: 113598-12-2
[5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; for 8h; Ambient temperature;
DOI:10.1021/jm00401a021

Reference yield:

: 88352-86-7
(furan-2-ylcarbonyl)methylamine hydrochloride

: 113598-12-2
[5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 80 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min

3: 93 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In water; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00401a021

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 113598-12-2
[5-Furan-2-yl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 80 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min

3: 93 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In water; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00401a021