methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate

Base Information

• Chemical Name: methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate
• CAS No.: 924891-30-5
• Molecular Formula: C₁₇H₂₀F₃NO₇
• Molecular Weight: 407.344
• Mol file: 924891-30-5.mol

Synonyms:methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate

Chemical Property of methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate

There total 2 articles about methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

methyl (4S)-5-(benzotriazol-1-yl)-5-oxo-4-(2,2,2-trifluoroacetamido)pentanoate (924891-09-8) + 1,2,3-trimethoxybenzene (621-23-8) → methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate (924891-30-5)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jo061667s

Reference yield:

(S)-5-methoxy-5-oxo-2-(2,2,2-trifluoroacetamido)pentanoic acid (688-19-7) → methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate (924891-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / CH₂Cl₂ / 0.5 h / Heating

1.2: 93 percent / CH₂Cl₂ / 2 h / 20 - 25 °C

2.1: 46 percent / TiCl₄ / CH₂Cl₂ / 20 °C

With thionyl chloride; titanium tetrachloride; In dichloromethane;

DOI:10.1021/jo061667s

Reference yield: 88.0%

methyl (4S)-5-oxo-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate (924891-30-5) → methyl (4S)-4-(2,2,2-trifluoroacetamido)-5-(2,4,6-trimethoxyphenyl)butanoate

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo061667s

upstream raw materials:

methyl (4S)-5-(benzotriazol-1-yl)-5-oxo-4-(2,2,2-trifluoroacetamido)pentanoate

1,2,3-trimethoxybenzene

(S)-5-methoxy-5-oxo-2-(2,2,2-trifluoroacetamido)pentanoic acid