4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Chemical Name:4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid
CAS No.:1561958-54-0
Molecular Formula:C₃₁H₄₃F₃N₄O₆S
Molecular Weight:656.767
Hs Code.:

4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Synonyms:4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Chemical Property of 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Technology Process of 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

There total 10 articles about 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1561958-52-8
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-cyano-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

: 1561958-54-0
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: With dihydrogen peroxide; potassium carbonate; In water; dimethyl sulfoxide; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561958-54-0
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 30 °C

2.1: tetrahydrofuran / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

5.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

6.1: N-Bromosuccinimide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

7.1: potassium iodide / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

9.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 2 h / 50 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; N-Bromosuccinimide; copper(l) iodide; ammonium cerium (IV) nitrate; dihydrogen peroxide; sodium hydride; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1561964-42-8
ethyl 5-(cyclohexyl(hydroxy)methyl)-1-(4-methoxybenzyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561958-54-0
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-2-carbamoyl-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

3.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

5.1: potassium iodide / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

7.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 2 h / 50 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; N-Bromosuccinimide; copper(l) iodide; ammonium cerium (IV) nitrate; dihydrogen peroxide; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;