2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Chemical Name:2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide
CAS No.:1616235-31-4
Molecular Formula:C₂₇H₁₈F₂N₈O
Molecular Weight:508.49
Hs Code.:

Synonyms:2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Chemical Property of 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Technology Process of 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

There total 9 articles about 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 402-65-3
2-fluoropyridine-4-carboxylic acid

: 1616235-97-2
6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

: 1616235-31-4
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1616235-79-0
3,3-dibromo-1-(4-fluorophenyl)prop-2-en-1-one

: 1616235-31-4
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Molecular sieve

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 0 - 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

5: hydrogenchloride; methanol / 1,4-dioxane / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1188146-14-6
5-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-31-4
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2: N-Bromosuccinimide / dichloromethane / 0 - 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

4: hydrogenchloride; methanol / 1,4-dioxane / 12 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;