Technology Process of (4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid
There total 10 articles about (4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C29H27ClN2O5;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 0 ℃;
pH=Ca. 6;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 20 °C
2.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 80 °C
3.1: triphenylphosphine; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
4.2: 0 °C / pH Ca. 6
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; triphenylphosphine; (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 15 - 20 °C
2.1: sodium methylate / methanol / 0.67 h / 0 - 25 °C
3.1: water; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C
3.2: pH Ca. 3 / Cooling with ice
4.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 80 °C
5.1: triphenylphosphine; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere
6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
6.2: 0 °C / pH Ca. 6
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium methylate; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
