8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1426260-95-8
Molecular Formula:C₂₅H₂₆FNO₂
Molecular Weight:391.485
Hs Code.:

Synonyms:8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1426260-91-4
8-bromo-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

: 1993-03-9
o-fluorophenylboronic acid

: 1426260-95-8
8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 8-bromo-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline; o-fluorophenylboronic acid; In isopropyl alcohol; for 0.5h;

With palladium diacetate; sodium carbonate; triphenylphosphine; In water; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 103-63-9
1-phenyl-2-bromoethane

: 1426260-95-8
8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 15 h / Reflux

1.2: 0.17 h / Inert atmosphere

2.1: lead(IV) tetraacetate; acetic acid / 20 °C

2.2: 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 8 h / 60 - 70 °C / Inert atmosphere

4.1: triphenylphosphine; sodium carbonate; palladium diacetate / isopropyl alcohol; water / 0.33 h / 120 °C / Microwave irradiation

With potassium tert-butylate; lead(IV) tetraacetate; palladium diacetate; sodium carbonate; acetic acid; triphenylphosphine; In water; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: |Suzuki Coupling;

Reference yield:

: 4602-73-7
3,4-dihydro-7-hydroxy-6-methoxy-isoquinoline

: 1426260-95-8
8-(2-fluorophenyl)-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 15 h / Reflux

1.2: 0.17 h / Inert atmosphere

2.1: lead(IV) tetraacetate; acetic acid / 20 °C

2.2: 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 8 h / 60 - 70 °C / Inert atmosphere

4.1: triphenylphosphine; sodium carbonate; palladium diacetate / isopropyl alcohol; water / 0.33 h / 120 °C / Microwave irradiation

With potassium tert-butylate; lead(IV) tetraacetate; palladium diacetate; sodium carbonate; acetic acid; triphenylphosphine; In water; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: |Suzuki Coupling;