N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Base Information

Chemical Name:N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide
CAS No.:1262337-62-1
Molecular Formula:C₂₁H₂₂FN₅O₃
Molecular Weight:411.436
Hs Code.:

Synonyms:N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Suppliers and Price of N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

There total 7 articles about N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1262339-00-3
N-(5-cyano-2-fluorophenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3-methylbutanamide

: 1262337-62-1
N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Guidance literature:: N-(5-cyano-2-fluorophenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3-methylbutanamide; With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; for 8h; Reflux;

With hydrogenchloride; In dichloromethane; water;
DOI:10.1021/ml200223s

Reference yield:

: 859855-53-1
3-amino-4-fluorobenzonitrile

: 1262337-62-1
N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 20 h / Dean-Stark apparatus; Reflux

1.2: 3.67 h / -10 - 20 °C

2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 50 °C

3.1: trimethylsilylazide / di(n-butyl)tin oxide / toluene / 8 h / Reflux

With 4-methyl-morpholine; trimethylsilylazide; toluene-4-sulfonic acid; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 1009-35-4
4-fluoro-3-nitrobenzonitrile

: 1262337-62-1
N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[2-fluoro-5-(1H-tetrazol-5-yl)phenyl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / isopropyl alcohol; water / 4 h / Reflux

2.1: toluene-4-sulfonic acid / toluene / 20 h / Dean-Stark apparatus; Reflux

2.2: 3.67 h / -10 - 20 °C

3.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: trimethylsilylazide / di(n-butyl)tin oxide / toluene / 8 h / Reflux

With 4-methyl-morpholine; trimethylsilylazide; iron; ammonium chloride; toluene-4-sulfonic acid; di(n-butyl)tin oxide; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;