4-Chloro-3,5-diiodopyridine

Base Information

• Chemical Name: 4-Chloro-3,5-diiodopyridine
• CAS No.: 13993-58-3
• Molecular Formula: C5H2 Cl I2 N
• Molecular Weight: 365.34
• Hs Code.: 2933399090
• Mol file: 13993-58-3.mol

Synonyms:4-Chloro-3,5-diiodopyridine

Chemical Property of 4-Chloro-3,5-diiodopyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.94420

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-3,5-Diiodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-3,5-diiodopyridine

There total 5 articles about 4-Chloro-3,5-diiodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-hydroxy-3,5-diiodopyridine (7153-08-4) → 4-chloro-3,5-diiodo-pyridine (13993-58-3)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 100 - 110 ℃; for 16h;

DOI:10.1039/b103148c

Reference yield:

3,5-diiodo-1H-pyridin-4-one (5579-93-1) → 4-chloro-3,5-diiodo-pyridine (13993-58-3)

Guidance literature:

With phosphorus pentachloride;

Reference yield:

4-pyridone (108-96-3,26266-70-6) → 4-chloro-3,5-diiodo-pyridine (13993-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide / acetonitrile / 3 h / Reflux

2: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 70 - 95 °C

With N-iodo-succinimide; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3,5-diiodo-1H-pyridin-4-one

4-hydroxy-3,5-diiodopyridine

pyridin-4-ol

4-pyridone

Downstream raw materials:

4-ethoxy-3,5-diiodopyridine

4-hydroxy-3,5-diiodopyridine

2,2'-dithiobenzoic acid

3,5-diiodo-pyridine-4-thiol