5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Base Information

Chemical Name:5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one
CAS No.:1229017-10-0
Molecular Formula:C₂₀H₂₇ClN₄O₄S
Molecular Weight:454.978
Hs Code.:

Synonyms:5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

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Chemical Property of 5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

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Technology Process of 5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

There total 6 articles about 5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 109-01-3
1-methyl-piperazine

: 1229019-46-8
2-(2-Ethoxyphenyl)-5-chloro-6-isopropylpyrimid-4(3H)-one

: 1229017-10-0
5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: 2-(2-Ethoxyphenyl)-5-chloro-6-isopropylpyrimid-4(3H)-one; With chlorosulfonic acid; at 0 ℃; for 2h;

1-methyl-piperazine; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/jm301159y

Reference yield:

: 879-57-2
2-ethoxy-N'-hydroxybenzenecarboximidamide

: 1229017-10-0
5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / 8 h / 65 °C / 22502.3 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

3.1: chlorine; pyridine / dichloromethane / 0.05 h / Cooling with ice

4.1: chlorosulfonic acid / 2 h / 0 °C

4.2: 0.17 h / 0 °C

With pyridine; chlorosulfonic acid; palladium 10% on activated carbon; hydrogen; chlorine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301159y

Reference yield:

: 913058-73-8
C₉H₁₂N₂O*C₂H₄O₂

: 1229017-10-0
5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: chlorine; pyridine / dichloromethane / 0.05 h / Cooling with ice

3.1: chlorosulfonic acid / 2 h / 0 °C

3.2: 0.17 h / 0 °C

With pyridine; chlorosulfonic acid; chlorine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301159y