4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Base Information

• Chemical Name: 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
• CAS No.: 1179803-73-6
• Molecular Formula: C₂₇H₂₂F₃N₃O₂
• Molecular Weight: 477.486
• Mol file: 1179803-73-6.mol

Synonyms:4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Chemical Property of 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

There total 9 articles about 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-benzylbenzyl bromide (55276-42-1) + 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (143782-20-1) → 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile (1179803-73-6)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 4h;

Reference yield:

C31H32F3N3O3 → 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile (1179803-73-6)

Guidance literature:

With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

2-benzylbenzaldehyde (32832-95-4) → 4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile (1179803-73-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / 1,1-dichloroethane / 20 °C / Reflux

2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 3750.38 Torr

3: acetonitrile / 20 °C

4: hydrogenchloride; water / acetonitrile / 3 h / 20 °C

With hydrogenchloride; water; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; 1,1-dichloroethane; dichloromethane; acetonitrile;

upstream raw materials:

2-benzylbenzyl bromide

4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

4-isocyanato-2-(trifluoromethyl)benzonitrile

tert-butyl 2-(2-benzylbenzylamino)-2-methylpropionate